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Valproic acid - CAS# 99-66-1 Size:Solid 10 mg 4-oxadiazol-5-yl)piperidin-1-yl)methanone

Valproic acid - CAS# 99-66-1 Size:Solid 10 mg 4-oxadiazol-5-yl)piperidin-1-yl)methanone

Name: Valproic acid - CAS# 99-66-1 Size:Solid 10 mg 4-oxadiazol-5-yl)piperidin-1-yl)methanone
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SKU: 43313413813
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SKU: 43313413813

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Valproic acid - CAS# 99-66-1 Size:Solid 10 mg 4-oxadiazol-5-yl)piperidin-1-yl)methanoneAI 10 49 is an inhibitor that binds the transcription factor fusion CBF SMMHC. AI 10 49, that selectively binds to CBF SMMHC and disrupts its binding to RUNX1. AI 10 49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice. Treatment of primary inv(16) AML patient blasts with AI 10 49 triggers selective cell death. These data suggest that direct inhibition of the oncogenic CBF SMMHC

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Description

4-oxadiazol-5-yl)piperidin-1-yl)methanone

MK-0591 has a high affinity for 5-lipoxygenase activating protein (FLAP) as evidenced by an IC50 value of 1

PubMed Central PMCID: PMC4460883

and HDAC3 (58 nM

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