glp 1 discontinuation GLP-1 Discontinuation: What It Means for Weight Loss Brands 🆙 GLP1 discontinuation after one

Compared with sulfonylureas users, GLP-1 users who used the medication for 0.5, 1 or 1.5 years before stopping the medication for the rest of the study period had no significant risk reductions for cardiovascular events

Safety and efficacy data through 6 months are available for 22 and 17 participants, respectively

(2025) T2DM: 46.5% discontinued by 1 year 64.1% discontinued by 2 years Without T2DM: 64.8% discontinued by 1 year 84.4% discontinued by 2 years Key Factors Linked to Discontinuation: Higher rates among patients without T2DM Age 65 years More likely to discontinue Higher weight loss during treatment Associated with lower discontinuation rates Moderate to severe GI side effects Higher likelihood of stopping treatment Higher income (T2DM only) Lower discontinuation rates Reinitiation of GLP-1: Source: Rodriguez PJ, Zhang V, Gratzl S, et al

GLP-1 medications have become a popular topic in the PCOS space, and its easy to see why