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Evening before bed is the dominant protocol because it amplifies the natural nocturnal GH surge (which peaks ~90 minutes into deep sleep)

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Together, this means rapidly activated efficient compensatory pathways and the ligation stop at the inferior caval vein efficiently bypassed (Vukojevic et al., 2018)

69,70 Patients in a phase 2 clinical trial employing curcumin in 21 patients with advanced pancreatic cancer demonstrated clinical indications of tumor regression after receiving 8 g/day of curcumin orally for 8 weeks